Croscarmellose Sodium Superdisintegrant rau Cov Tshuaj Ntsuas Tshuaj | O sai, Qib siv tsawg 0.5-5% | Ua raws li USP/EP/JP

Peb cov Croscarmellose Sodium yog ib qho tshuaj superdisintegrant purity siab uas tsim los rau cov qauv tshuaj khov kho hauv qhov ncauj xws li cov ntsiav tshuaj, tshuaj ntsiav, thiab cov granules. Nws yog ib qho sodium carboxymethylcellulose uas txuas nrog sab hauv uas tsis yaj hauv dej tab sis sai sai swells mus rau 4-8 npaug ntawm nws qhov ntim thawj zaug thaum kov cov dej hauv nruab nrab.Cov qauv fibrous tshwj xeeb no muab cov dej zoo heev thiab kev ua haujlwm capillary, ua rau cov ntsiav tshuaj tawg zoo dua thiab ua kom cov tshuaj yaj zoo dua.Ua raws li USP-NF, EP, JP, thiab ChP pharmacopoeias nrog CDE sau npe F20209990136. Qib siv ib txwm muaj: 0.5-5.0% w/w (2% rau kev nias ncaj qha, 3% rau kev ua kom ntub dej)Haum rau kev nias ncaj qha, kev sib xyaw ua ke ntub (sab hauv lossis sab nraud), kev sib xyaw ua ke ntawm cov menyuam, thiab cov tshuaj ntsiav.

Tiv tauj peb

Cov Khoom Qhia Txog Khoom

Tshuaj Qib Croscarmellose Sodium (CCS)

Txheej Txheem Cej Luam Khoom

Croscarmellose Sodium yog ib qho sodium carboxymethylcellulose uas txuas nrog sab hauv, tsim tshwj xeeb rau kev siv ua superdisintegrant hauv cov tshuaj formulations.Tsis zoo li cov tshuaj yaj uas ib txwm muaj, nws muab cov khoom yaj zoo heev ntawm cov concentration qis, ua kom cov ntsiav tshuaj tawg sai thiab ua kom cov tshuaj yaj zoo dua rau kev siv tau zoo dua..

Lub Npe Khoom:

Lub Npe Tshuaj:Croscarmellose Sodium
Tus lej CAS:74811-65-7
Tus lej rau npe CDE:F20209990136
Kev Ua Raws Cai ntawm Pharmacopoeia:ChP, USP-NF, EP, JP, BP
Tus lej EC:629-739-2
Cov lus txhais:Carboxymethylcellulose Sodium uas txuas nrog, CCNa, Sodium Croscarmellose, E468

Cov Nta Tseem Ceeb & Cov Txiaj Ntsig

1. Kev Ua Kom Tawg Zoo Tshaj Plaws

Kev tawg ua ob zaug:Ua ke cov capillary action (wicking) nrog rau kev o sai
Ntsws mus rau4-8 npaug ntawm nws qhov ntim thawjthaum kov dej
Cov qauv fibrous muab cov peev xwm nqus dej zoo heev
Tsim kev nthuav dav uas ua rau cov ntsiav tshuaj tawg sai sai

2. Qib Siv Tsawg - Kev Ua Haujlwm Zoo

Zoo rau ntawm cov concentration qis li0.5-5.0% w/w
Kev siv ib txwm muaj: 2% rau kev nias ncaj qha, 3% rau kev ua kom cov granules ntub
Kev daws teeb meem pheej yig rau kev tsim cov qauv

3. Kev Yooj Yim Rau Kev Tsim Khoom

Haum rau txhua txoj kev ua ntsiav tshuaj: kev nias ncaj qha, kev sib xyaw ua hmoov ntub, kev sib xyaw ua hmoov rau cov menyuam
Hauv kev ua granulation ntub, siv tau rau hauv cov granular, ntxiv cov granular, lossis faib ua ob theem
Sib xws nrog cov tshuaj capsule (siv 10-25%)

4. Cov Khoom Siv Lub Cev Zoo Kawg Nkaus

Tsos:Dawb rau dawb, hmoov dawb ntws
Qib ntawm Kev Hloov Chaw:0.60 – 0.85
Kev Kho Kom Tiav Ntim:10.0 – 30.0 ml
pH (1% kua):5.0 – 7.0
Poob thaum ziab:≤10.0%
Cov Khoom seem ntawm kev sib txuas:14.0% – 28.0%
Cov Khoom Uas Yaj Tau Hauv Dej:≤10.0%
Cov Hlau Hnyav:≤10 ppm

5. API Sib Xws & Kev Ruaj Ntseg

Puas yogtsis muaj cov peroxides- ua kom muaj kev ruaj khov zoo dua rau cov APIs uas rhiab heev rau oxidation
Tsis muaj kev cuam tshuam tsis zoo rau qhov tawv ntawm lub ntsiav tshuaj lossis qhov friability
Kev ua haujlwm ntawm kev tawg ua rau tsis sib xws tas li thaum lub sijhawm
Tsis yog GMO, tsis muaj allergen